Multicompartment polymersome gel for encapsulation

Multicompartment polymersome gel for encapsulation

We introduce an approach that combines the concepts of emulsiontemplating and dewetting for fabricating polymersomes with a large number of compartments. The resultant polymersome gel behaves as a gel-like solid, but is a true vesicle suspended in an aqueous environment. Due to the thin membranes that separate the compartments, the polymersome gels have a high volume fraction of internal phase ...

Title Multicompartment polymersome gel for encapsulation

Aqueous Sol-Gel Process for Protein Encapsulation

Porous silica materials made by low-temperature sol-gel process are promising host matrixes for encapsulation of biomolecules. To date, researchers have focused on sol-gel routes using alkoxides such as tetramethyl orthosilicate (TMOS) and tetraethyl orthosilicate (TEOS) for encapsulation of biomolecules. These routes lead to formation of alcohol as a byproduct that can have a detrimental effec...

A charge neutral, size tuneable polymersome capable of high biological encapsulation efficiency and cell permeation.

The field of therapeutics is evolving to include a greater proportion of higher molecular weight, hydrophilic biological compounds. To cater for this new era in healthcare the concomitant development of appropriate drug delivery systems is essential to aid cellular permeation. In this manuscript we present the synthesis, characterisation and biological evaluation of a charge neutral polymersome...

Gel encapsulation of glucose nanosensors for prolonged in vivo lifetime.

BACKGROUND Fluorescent glucose-sensitive nanosensors have previously been used in vivo to track glucose concentration changes in interstitial fluid. However, this technology was limited because of loss of fluorescence intensity due to particle diffusion from the injection site. In this study, we encapsulated the nanosensors into injectable gels to mitigate nanosensor migration in vivo. ...